|
Antiinfectives
General Rx
Renal Rx
Transplant Rx
Pkinetics
Educational
KidneyWorks
Clinical Tools
|
Calcium Carbonate (CaCO3)
 |
Actions and Uses |
Antacid and Phosphate Binder. Binds dietary phosphate and neutralizes gastric acid. It is used as a phosphate binder (to reduce phosphate level in chronic renal failure pts), an antacids, and as a calcium supplement.
|
Available As |
Tablets (500 or 650 mg), oral suspension (1250 mg/5mL)
|
Dose and Administration |
- Dosage ranges from 650 mg once daily to 1950 mg three times daily.
- 40% of CaCO3 wt is elemental Ca++
- Avoid giving within 3 hrs of oral mycophenolate, oral fluoroquinolones (ofloxacin, cipro, etc) and other interacting drugs.
|
Pharmacokinetics |
- Ca++ absorption is regulated via parathormone (PTH) and calcitriol.
|
Side Effects |
- Constipation
- Milk-alkali syndrome (metabolic alkalosis)
|
Drug Interactions |
- Interferes with the absorption of many drugs.
- Avoid administring divalent cations like calcium within 2-4 hrs of mycophenolate, oral fluoroquinolone, and other interacting medications
|
